Class 12 Chemistry Surface Chemistry Mechanism of enzyme catalysis

Mechanism of enzyme catalysis

Enzyme-catalysed reactions usually proceed in 2 steps-

  1. Binding of the enzyme to the substrate to form an activated complex

E + S -->  ES*

  1. Decomposition of activated complex

ES*  -->  E +P

where E- Enzyme,   S- Substrate ,    ES*- Activated complex ,     P- Product

Lock and Key Mechanism- There are many cavities present on the surface of the enzyme. These cavities have a characteristic shape and active groups like  –NH2,  COOH, -SH, -OH etc. These are actually the active centres on the surface of the enzyme. The reactant molecules which have a complementary shape can fit into these cavities a lot like a key fitting into a lock. Due to the active centres (groups) present an activated complex also called enzyme-substrate complex is formed.

This complex decomposes to give products and the enzyme.

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